Search results for "molecular autopsy"

Molecular autopsy in sudden cardiac death and genetic screen in arrhythmogenic cardiac syndromes.

Sudden cardiac death (SCD) is one of the most important mode of death in Western Countries and remains a major public health problems; is responsible for half of all deaths due to cardiovascular disease. New methods of preventing potentially fatal arrhythmias have been developed, and the accurate diagnosis of the causes of Sudden Cardiac Death is now of particular importance. In recent years researchers have identified the genetic background of many diseases involving the myocardium, and many Cardiomyopathies are considered to have a genetic origin. Specialized myocytes of the cardiac conduction system are essential to coordinate sequential contraction of cardiac atria and ventricles. Anoma…

Pharmacogenetics and Forensic Toxicology: A New Step towards a Multidisciplinary Approach

2021

Pharmacogenetics analyzes the individual behavior of DNA genes after the administration of a drug. Pharmacogenetic research has been implemented in recent years thanks to the improvement in genome sequencing techniques and molecular genetics. In addition to medical purposes, pharmacogenetics can constitute an important tool for clarifying the interpretation of toxicological data in post-mortem examinations, sometimes crucial for determining the cause and modality of death. The purpose of this systematic literature review is not only to raise awareness among the forensic community concerning pharmacogenetics, but also to provide a workflow for forensic toxicologists to follow in cases of unk…